Efficient production of an antitumor precursor actinocin and other medicinal molecules from kynurenine pathway in Escherichia coli.

Sharma, Komal; Ghiffary, Mohammad Rifqi; Lee, GaRyoung; Kim, Hyun Uk

Sharma, Komal; Ghiffary, Mohammad Rifqi; Lee, GaRyoung; Kim, Hyun Uk.

Affiliation

Sharma K; Systems Biology and Medicine Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Ghiffary MR; Systems Biology and Medicine Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Lee G; Systems Biology and Medicine Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Kim HU; Systems Biology and Medicine Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea; Graduate School of Engineering Biology, KAIST, Daejeon, 34141, Republic of Korea; BioProcess Engineering Resear

Metab Eng ; 81: 144-156, 2024 Jan.

Article in En | MEDLINE | ID: mdl-38043641

Subject(s)

Escherichia coli; Kynurenine; Oxazines; Kynurenine/genetics; Kynurenine/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Tryptophan/genetics; Tryptophan/metabolism; Glucose/genetics; Glucose/metabolism; Metabolic Engineering; Biosynthetic Pathways

Key words

Actinocin; Escherichia coli; Heterologous expression; Kynurenine pathway; Medicinal molecules; Metabolic engineering

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