Illuminating the understudied GPCR-ome.
Drug Discov Today
; 29(3): 103848, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38052317
ABSTRACT
G-protein-coupled receptors (GPCRs) are the target of >30% of approved drugs. Despite their popularity, many of the >800 human GPCRs remain understudied. The Illuminating the Druggable Genome (IDG) project has generated many tools leading to important insights into the function and druggability of these so-called 'dark' receptors. These tools include assays, such as PRESTO-TANGO and TRUPATH, billions of small molecules made available via the ZINC virtual library, solved orphan GPCR structures, GPCR knock-in mice, and more. Together, these tools are illuminating the remaining 'dark' GPCRs.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Biological Assay
/
Receptors, G-Protein-Coupled
Limits:
Animals
/
Humans
Language:
En
Year:
2024
Type:
Article