miR-92a-3p-inspired shRNA exhibits pro-chondrogenic and chondrocyte protective effects in osteoarthritis treatment through targeting SMAD6/7.

Zheng, Chenhuang; Hoshi, Kazuto; Hikita, Atsuhiko

Zheng, Chenhuang; Hoshi, Kazuto; Hikita, Atsuhiko.

Affiliation

Zheng C; Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Hoshi K; Department of Tissue Engineering, The University of Tokyo Hospital, Bunkyo City, 7 Chome-3-1 Hongo, Tokyo, 113-8655, Japan.
Hikita A; Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.

J Bone Miner Metab ; 42(1): 1-16, 2024 Jan.

Article in En | MEDLINE | ID: mdl-38055109

Subject(s)

MicroRNAs; Osteoarthritis; Humans; Animals; Mice; Chondrocytes/metabolism; MicroRNAs/genetics; MicroRNAs/metabolism; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Collagen Type II/metabolism; Aggrecans/metabolism; Quality of Life; Mice, Inbred C57BL; Osteoarthritis/genetics; Osteoarthritis/therapy; Osteoarthritis/metabolism; Smad Proteins/metabolism; Biomarkers/metabolism; Luciferases/metabolism; Luciferases/pharmacology; Smad6 Protein/metabolism; Smad6 Protein/pharmacology

Key words

Adipose-derived stem cells; Osteoarthritis; miR-92a-3p

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Osteoarthritis / MicroRNAs Limits: Animals / Humans Language: En Year: 2024 Type: Article

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Osteoarthritis / MicroRNAs Limits: Animals / Humans Language: En Year: 2024 Type: Article