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Increasing the versatility of the biphenyl-fused-dioxacyclodecyne class of strained alkynes.
Forshaw, Sam; Parker, Jeremy S; Scott, William T; Knighton, Richard C; Tiwari, Neelam; Oladeji, Samson M; Stevens, Andrew C; Chew, Yean Ming; Reber, Jami; Clarkson, Guy J; Balasubramanian, Mohan K; Wills, Martin.
Affiliation
  • Forshaw S; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
  • Parker JS; Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield, SK10 2NA, UK.
  • Scott WT; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
  • Knighton RC; Warwick Medical School, The University of Warwick, Coventry, CV4 7AL, UK.
  • Tiwari N; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
  • Oladeji SM; School of Chemistry, University of Southampton, SO17 1BJ, UK.
  • Stevens AC; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
  • Chew YM; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
  • Reber J; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
  • Clarkson GJ; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
  • Balasubramanian MK; Warwick Medical School, The University of Warwick, Coventry, CV4 7AL, UK.
  • Wills M; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
Org Biomol Chem ; 22(3): 590-605, 2024 Jan 17.
Article in En | MEDLINE | ID: mdl-38131271
ABSTRACT
Biphenyl-fused-dioxacyclodecynes are a promising class of strained alkyne for use in Cu-free 'click' reactions. In this paper, a series of functionalised derivatives of this class of reagent, containing fluorescent groups, are described. Studies aimed at understanding and increasing the reactivity of the alkynes are also presented, together with an investigation of the bioconjugation of the reagents with an azide-labelled protein.
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Full text: 1 Database: MEDLINE Language: En Year: 2024 Type: Article
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Full text: 1 Database: MEDLINE Language: En Year: 2024 Type: Article