Breast Cancer-related Lymphedema: Recent Updates on Clinical Efficacy of Therapies and Bioengineering Approaches for a Personalized Therapy.
Curr Pharm Des
; 30(1): 63-70, 2024.
Article
in En
| MEDLINE
| ID: mdl-38141193
ABSTRACT
BACKGROUND:
Post-mastectomy lymphedema is a chronic progressive disease characterized by a significant reduction in quality of life and a range of complications.AIM:
To this date, no single treatment method provides pathological correction of the mechanisms associated with tissue reorganization observed in later-stage breast cancer-related lymphedema (BCRL).METHODS:
To define a personalized approach to the management of patients with iatrogenic lymphedema, we performed a systematic review of literature without a comprehensive meta-analysis to outline existing molecular- genetic patterns, overview current treatment methods and their efficacy, and highlight the specific tissue-associated changes in BCRL conditions and other bio-engineering approaches to develop personalized therapy.RESULTS:
Our results show that several tissue-specific and pathological molecular markers may be found, yet current research does not aim to define them.CONCLUSION:
As such, currently, a strong foundation for further research into molecular-genetic changes in lymphedema tissue exists, and further research should focus on finding specific targets for personalized treatment through bio-engineering approaches.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Breast Cancer Lymphedema
Limits:
Female
/
Humans
Language:
En
Year:
2024
Type:
Article