Signalling of Adrenoceptors: Canonical Pathways and New Paradigms.
Handb Exp Pharmacol
; 285: 147-184, 2024.
Article
in En
| MEDLINE
| ID: mdl-38227198
ABSTRACT
The concept of G protein-coupled receptors initially arose from studies of the ß-adrenoceptor, adenylyl cyclase, and cAMP signalling pathway. Since then both canonical G protein-coupled receptor signalling pathways and emerging paradigms in receptor signalling have been defined by experiments focused on adrenoceptors. Here, we discuss the evidence for G protein coupling specificity of the nine adrenoceptor subtypes. We summarise the ability of each of the adrenoceptors to activate proximal signalling mediators including cAMP, calcium, mitogen-activated protein kinases, and protein kinase C pathways. Finally, we highlight the importance of precise spatial and temporal control of adrenoceptor signalling that is controlled by the localisation of receptors at intracellular membranes and in larger protein complexes.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Signal Transduction
/
Receptors, Adrenergic
Limits:
Animals
/
Humans
Language:
En
Year:
2024
Type:
Article