Allergic rhinitis phenotypes with distinct transcriptome profiles in children: A birth cohort.
J Allergy Clin Immunol
; 153(5): 1319-1329, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38242217
ABSTRACT
BACKGROUND:
Allergic rhinitis (AR) phenotypes in childhood are unclear.OBJECTIVES:
This study sought to determine AR phenotypes and investigate their natural course and clinical and transcriptomic characteristics.METHODS:
Latent class trajectory analysis was used for phenotyping AR in 1050 children from birth through 12 years using a birth cohort study. Blood transcriptome analyses were performed to define the underlying mechanisms of each phenotype.RESULTS:
Five AR phenotypes were identified early onset (n = 88, 8.4%), intermediate transient (n = 110, 10.5%), late onset (n = 209, 19.9%), very late onset (n=187, 17.8%), and never/infrequent (n = 456, 43.4%). Children with early-onset AR were associated with higher AR severity and sensitizations to foods at age 1 year and inhalants at age 3 years and asthma symptoms, but not with bronchial hyperresponsiveness (BHR). Children with late-onset AR phenotype associated with sensitizations to various foods at age 1 year but not from age 3 years, and to inhalants from age 7 years and with asthma with BHR. Children with very late-onset AR phenotype associated with sensitizations to foods throughout preschool age and to inhalants at ages 7 and 9 years and with asthma with BHR. Transcriptome analysis showed that early-onset AR was associated with viral/bacterial infection-related defense response, whereas late-onset AR was associated with T cell-related immune response.CONCLUSIONS:
Early-onset AR phenotype was associated with sensitization to foods and inhalants at an early age and asthma symptoms, but not with BHR, whereas very late- and late-onset AR phenotypes were positively associated with sensitization to inhalants and asthma with BHR. Transcriptomic analyses indicated that early- and late-onset AR phenotypes had distinct underlying mechanisms related to AR as well.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Phenotype
/
Transcriptome
/
Rhinitis, Allergic
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
En
Year:
2024
Type:
Article