Naphthalimide-based Functional Glycopolymeric Nanoparticles as Fluorescent Probes for Selective Imaging of Tumor Cells.
Chemistry
; 30(17): e202304165, 2024 Mar 20.
Article
in En
| MEDLINE
| ID: mdl-38246871
ABSTRACT
A series of functional glycopolymer nanoparticles with 1,8-naphthalimide motif was designed, synthesized and applied for tumor cell imaging. With the pH-sensitive and aggregation-induced emission (AIE) effect of the 1,8-naphthalimide fluorescent probe, the presence of glucose-based glycopolymers enhanced its water-solubility and biocompatibility. Owing to the dual tumor-targeting effects of the dense glucose part and the boronic ester modification, the obtained glycopolymers showed high affinity to tumor cells, with a much faster staining rate than normal cells, indicating a great potential for diagnosis and treatments of cancers.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Nanoparticles
/
Fluorescent Dyes
Language:
En
Year:
2024
Type:
Article