Evidence for cell-mediated autoimmunity in patients with pemphigus vulgaris and bullous pemphigoid.
Arch Dermatol Res
; 265(1): 9-14, 1979 May 29.
Article
in En
| MEDLINE
| ID: mdl-383026
ABSTRACT
Lymphoid cells from 4 of 5 patients diagnosed as pemphigus vulgaris (PV) and 6 of 7 patients diagnosed as bullous pemphigoid (BP) demonstrated specific cell-mediated immunity by the production of migration inhibitory factor (MIF) in the presence of autologous epidermal saline extracts. Clinical treatment of these patients with immunosuppressive agents resulted in a state of unresponsiveness of their lymphoid cells to similar concentrations of the antigen. Controls consisted of lymphoid cells from patients with bullous burns or various drug allergies which failed to show significant MIF production in the presence of autologous skin extract. These studies suggest that both PV and BP patients posses cell-mediated immunity (CMI) to their own autologous tissue antigens and this CMI may play a role in the pathogenesis of these diseases.
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Database:
MEDLINE
Main subject:
Autoantibodies
/
Cell Migration Inhibition
/
Skin Diseases, Vesiculobullous
/
Pemphigus
/
Immunity, Cellular
Type of study:
Etiology_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
1979
Type:
Article