Therapeutic Peptides Are Preferentially Solubilized in Specific Microenvironments within PEG-PLGA Polymer Nanoparticles.

López-Rios de Castro, Raquel; Ziolek, Robert M; Ulmschneider, Martin B; Lorenz, Christian D

López-Rios de Castro, Raquel; Ziolek, Robert M; Ulmschneider, Martin B; Lorenz, Christian D.

Affiliation

López-Rios de Castro R; Department of Chemistry, King's College London, London SE1 1DB, United Kingdom.
Ziolek RM; Biological Physics and Soft Matter Group, Department of Physics, King's College London, London WC2R 2LS, United Kingdom.
Ulmschneider MB; Biological Physics and Soft Matter Group, Department of Physics, King's College London, London WC2R 2LS, United Kingdom.
Lorenz CD; Kvantify Aps, DK-2300 Copenhagen S, Denmark.

Nano Lett ; 24(6): 2011-2017, 2024 Feb 14.

Article in En | MEDLINE | ID: mdl-38306708

Subject(s)

Nanoparticles; Polyesters; Polymers; Polymers/chemistry; Lactic Acid/chemistry; Polyethylene Glycols/chemistry; Drug Delivery Systems/methods; Peptides; Nanoparticles/chemistry; Drug Carriers/chemistry

Key words

Molecular dynamics simulations; PEG; PLGA; drug delivery vehicles; polymer nanoparticles

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