Association of air quality index (AQI) with incidence of atopic dermatitis in Taiwan: A nationwide population-based cohort study.
J Am Acad Dermatol
; 90(6): 1218-1225, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38311242
ABSTRACT
BACKGROUND:
Air pollutants may aggravate atopic dermatitis (AD). However, the association between Air Quality Index (AQI) and incidence of AD remains unknown.OBJECTIVE:
To investigate association between AQI and incidence of AD, using the nationwide cohort in the Taiwan National Health Insurance Research Database (NHIRD).METHODS:
We included 21,278,938 participants from the NHIRD not diagnosed with AD before 2008. Long-term average AQI value, obtained from the Taiwan Air Quality Monitoring System Network, before AD diagnosis was calculated and linked for each participant.RESULTS:
199,205 incident cases of AD were identified from 2008 to 2018. Participants were classified into 4 quantiles (Q) by AQI value. With the lowest quantile, Q1, as reference, the AD risk increased significantly in the Q2 group (adjusted hazard ratio [aHR] 1.29, 95% confidence interval [CI] 1.04-1.65), Q3 group (aHR 4.71, 95% CI 3.78-6.04), and was highest in the Q4 group (aHR 13.20, 95% CI 10.86-16.60). As AQI treated as a continuous variable, an increase of 1 unit of AQI value added 7% of AD risk (aHR, 1.07, 95% CI 1.07-1.08).LIMITATIONS:
The NHIRD lacks detailed information on individual subjects.CONCLUSIONS:
The results demonstrated a significant positive association between AQI and incidence of AD with a clear dose-response relationship.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Dermatitis, Atopic
/
Air Pollution
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
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Child, preschool
/
Female
/
Humans
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Infant
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Year:
2024
Type:
Article