Apelin-13 alleviates osteoclast formation and osteolysis through Nrf2-pyroptosis pathway.
Microsc Res Tech
; 87(6): 1348-1358, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38380581
ABSTRACT
Wear particle-induced periprosthetic osteolysis is the key to aseptic loosening after artificial joint replacement. Osteoclastogenesis plays a central role in this process. Apelin-13 is a member of the adipokine family with anti-inflammatory effects. Here, we report that apelin-13 alleviates RANKL-mediated osteoclast differentiation and titanium particle-induced osteolysis in mouse calvaria. Mechanistically, apelin-13 inhibits NLRP3 inflammasome-mediated pyroptosis by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. In summary, apelin-13 is expected to be a potential drug for relieving aseptic osteolysis. RESEARCH HIGHLIGHTS This study reveals the molecular mechanism by which apelin-13 inhibits NLRP3 inflammasome activation and pyroptosis by promoting Nrf2. This study confirms that apelin-13 alleviates osteoclast activation by inhibiting pyroptosis. In vivo studies further confirmed that apelin-13 alleviated mouse skull osteolysis by inhibiting the activation of NLRP3 inflammasome.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Osteoclasts
/
Osteolysis
/
Intercellular Signaling Peptides and Proteins
Limits:
Animals
Language:
En
Year:
2024
Type:
Article