Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system.
Nat Immunol
; 25(3): 405-417, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38413722
ABSTRACT
The immune system comprises diverse specialized cell types that cooperate to defend the host against a wide range of pathogenic threats. Recent advancements in single-cell and spatial multi-omics technologies provide rich information about the molecular state of immune cells. Here, we review how the integration of single-cell and spatial multi-omics data with prior knowledge-gathered from decades of detailed biochemical studies-allows us to obtain functional insights, focusing on gene regulatory processes and cell-cell interactions. We present diverse applications in immunology and critically assess underlying assumptions and limitations. Finally, we offer a perspective on the ongoing technological and algorithmic developments that promise to get us closer to a systemic mechanistic understanding of the immune system.
Full text:
1
Database:
MEDLINE
Main subject:
Multiomics
/
Immune System
Language:
En
Year:
2024
Type:
Article