Prevalence of Duffy null and its impact on hydroxyurea in young children with sickle cell disease in the United States.
Pediatr Blood Cancer
; 71(6): e30945, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38462769
ABSTRACT
Consistent with studies showing a high prevalence of the Duffy null phenotype among healthy Black Americans, this retrospective study found that Duffy null was present in >75% of a young and contemporary cohort of children with sickle cell disease (SCD) in the United States. Despite the potential for this phenotype to impact absolute neutrophil counts, hydroxyurea (HU) dosing, and outcomes, it was not associated with being prescribed a lower HU dose or having increased acute SCD visits early in the HU treatment course. Future studies are needed to confirm these findings in older children with SCD.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Duffy Blood-Group System
/
Hydroxyurea
/
Anemia, Sickle Cell
/
Antisickling Agents
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
Country/Region as subject:
America do norte
Language:
En
Year:
2024
Type:
Article