Anti-Inflammatory Sesquiterpenes from Fruiting Bodies of Schizophyllum commune.
J Agric Food Chem
; 72(10): 5416-5427, 2024 Mar 13.
Article
in En
| MEDLINE
| ID: mdl-38477043
ABSTRACT
Schizophyllum commune, a fleshy fungus, is an important medicinal and food-homologous mushroom in China. In this work, eight undescribed sesquiterpenes schizomycins A-H (1-8) and one new meroterpenoid schizomycin I (9) together with three known analogues (10-12) were isolated from fruiting bodies of S. commune. Their planar structures were established by extensive spectroscopic and mass spectrometric data. The absolute configurations of compounds 1, 2, and 4 were determined by single crystal X-ray diffraction, and compounds 3 and 5-9 were confirmed by electronic circular dichroism calculations. Anti-inflammatory activities of all isolated compounds were evaluated for their inhibitory effects on IL-6 and IL-1ß production in RAW 264.7 cells. Among them, compound 7 exhibited significant IL-6 inhibitory activity with an IC50 value of 3.6 µM. The results of molecular docking showed that compound 7 interacts with amino acid residues (Gly117, Lys118, Asp120, Thr166, and Try168) of the IL-6 receptor protein through hydrogen bonding.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Ascomycota
/
Schizophyllum
/
Sesquiterpenes
Language:
En
Year:
2024
Type:
Article