ABSTRACT
BACKGROUND:
The use of
continuous renal replacement therapy (CRRT) in
critically ill children is rapidly increasing, but the
standard of care has not yet been established and
prognosis remains poor. To develop optimal CRRT
strategies, we launched a
research project generating the
Japanese Pediatric CRRT
registry, a multicenter
registry of CRRT in
Japanese pediatric intensive care units (PICUs), to investigate the actual status of CRRT in recent years in PICUs, where data are lacking.
METHODS:
This manuscript presents a protocol for
planning a multicenter prospective
registry. As of April 2023, 15
Japanese PICUs are voluntarily participating.
Patients enrolled are those <16 years of age
who enter the PICUs of the collaborating institutions, require CRRT, and have the guardians' consent. CRRT is defined as anticipated to be required for >24 hours, and CRRT connected to
extracorporeal membrane oxygenation is also included. The
registry is an online
registry system managed by the
University Hospital Medical
Information Network. The primary outcomes are Pediatric Cerebral Performance Category Scale at PICU discharge and 6 months post-discharge (deaths included), persistent need for
dialysis, and PICU readmission within 6 months. The
secondary outcomes are adverse events during and immediately after CRRT initiation, and initial circuit
life span.
CONCLUSIONS:
This project
will examine the differences in outcomes of CRRT in PICUs in specific
patient and
treatment groups and
will be used to design
future interventional studies. We
will also aim to establish a platform for a multicenter
registry study in
Japanese PICUs, considering the current lack of such a platform.