Association of serum uric acid with all-cause and cardiovascular mortality in chronic kidney disease stages 3-5.
Nutr Metab Cardiovasc Dis
; 34(6): 1518-1527, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38508991
ABSTRACT
BACKGROUND AND AIMS:
The role of serum uric acid (SUA) in the prognosis of chronic kidney disease (CKD) is inconclusive. To explore the association of SUA level with all-cause and cardiovascular disease (CVD) mortality in patients with CKD. METHODS ANDRESULTS:
Leveraging data from the National Health and Nutritional Examination Survey (NHANES) and linked national death records up to December 31 2019, we explored the association of SUA with all-cause and CVD mortality using weighted cox proportional hazards regression models and restricted cubic spline (RCS) models in patients with CKD stages 3-5. The study finally included 2644 patients with CKD stages 3-5, with a median SUA level of 6.5 mg/dL. After a median follow-up of 55 months, a total of 763 deaths were recorded, with 279 of them attributed to CVD. In the fully adjusted model, per 1 mg/dL increment in SUA concentration was found to be associated with increased HRs (95% CIs) of 1.07 (1.00, 1.14) for all-cause mortality and 1.11 (1.00, 1.24) for CVD mortality. Compared to Q2 (reference), those in Q4 had adjusted HRs of 1.72 (1.36, 2.17) for all-cause mortality and 2.17 (1.38, 3.41) for CVD mortality, while those in Q1 had adjusted HRs of 1.49 (1.19, 1.85) for all-cause mortality and 1.93 (1.26, 2.98) for CVD mortality.CONCLUSIONS:
Both higher and lower SUA levels were associated with increased risks of all-cause and CVD mortality in patients with CKD stages 3-5.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Uric Acid
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Biomarkers
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Cardiovascular Diseases
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Nutrition Surveys
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Cause of Death
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Hyperuricemia
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Renal Insufficiency, Chronic
Limits:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Year:
2024
Type:
Article