ABSTRACT
Background:
Evidence from observational studies and clinical trials suggests that the allergic
diseases (ADs) are associated with
kidney diseases (KDs). However, the causal
association between them remains to be determined. We used bidirectional two-sample Mendelian
randomization (MR)
analysis to evaluate the potential
causality between them.
Methods:
Mendelian
randomization (MR) was performed using publicly available
genome-wide association study (GWAS) summary datasets. Inverse variance weighted (IVW), weighted median, MR-Egger regression, simple mode, and weighted mode
methods are used to evaluate the
causality between ADs and KDs.
Sensitivity and heterogeneity analyses were used to ensure the stability of the results.
Results:
The MR results indicated that
genetic susceptibility to ADs was associated with a higher
risk of CKD [
odds ratio (OR) = 1.124, 95% CI = 1.020-1.239, p = 0.019] and unspecified
kidney failure (OR = 1.170, 95% CI = 1.004-1.363, p = 0.045) but not with
kidney stone,
ureter stone or
bladder stone (OR = 1.001, 95% CI = 1.000-1.002, p = 0.216), other renal or
kidney problem (OR = 1.000, 95% CI = 1.000-1.001, p = 0.339),
urinary tract or
kidney infection (OR = 1.000, 95% CI = 0.999-1.001, p = 0.604),
kidney volume (OR = 0.996, 95% CI = 0.960-1.033, p = 0.812) and
cyst of
kidney (OR = 0.914, 95% CI = 0.756-1.105, p = 0.354). No causal evidence of KDs on ADs was found in present study.
Conclusion:
Results from MR
analysis indicate a causal
association between ADs and CKD and unspecified
kidney failure. These findings partly suggest that early
monitoring of CKD
risk in
patients with ADs is intentional.