Enrichment of liver MAIT cells in a mouse model of Alzheimer's disease.
J Neuroimmunol
; 390: 578332, 2024 May 15.
Article
in En
| MEDLINE
| ID: mdl-38537322
ABSTRACT
Emerging evidence has supported a role for the immune system and liver in Alzheimer's disease (AD). However, our understanding of how hepatic immune cells are altered in AD is limited. We previously found that brain mucosal-associated invariant T (MAIT) cell numbers are increased in AD. Furthermore, loss of MAIT cells and their antigen-presenting molecule, MR1, reduced amyloid-ß accumulation in the brain. MAIT cells are also significantly present in the liver. Therefore, we sought to analyze MAIT and other immune cells in the AD liver. Increased frequency of activated MAIT cells (but not conventional T cells) were found in 8-month-old 5XFAD mouse livers. Therefore, these data raise the possibility that there is a role for peripheral MAIT cells in AD pathology.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Mice, Transgenic
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Disease Models, Animal
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Alzheimer Disease
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Mucosal-Associated Invariant T Cells
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Liver
Limits:
Animals
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Female
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Humans
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Male
Language:
En
Year:
2024
Type:
Article