Genomic Insights and Synthetic Biology Applications of Marine Actinomycete Streptomyces griseoincarnatus HNS054.
Int J Mol Sci
; 25(6)2024 Mar 08.
Article
in En
| MEDLINE
| ID: mdl-38542100
ABSTRACT
The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to S. coelicolor M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Streptomyces
/
Biological Products
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Actinobacteria
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Streptomyces coelicolor
Language:
En
Year:
2024
Type:
Article