Relapsing bronchopneumonia due to community-associated methicillin-resistant Staphylococcus aureus: a case report.
BMC Infect Dis
; 24(1): 374, 2024 Apr 04.
Article
in En
| MEDLINE
| ID: mdl-38575909
ABSTRACT
BACKGROUND:
The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has increased the incidence of community-onset MRSA infection. Respiratory tract infections caused by MRSA has been noted for their severity; however, repeated relapses that require extended antibiotic therapy are rare. CASE PRESENTATION We report a case of relapsing bronchopneumonia caused by CA-MRSA in a 56-year-old man. The patient responded to antibiotics, but repeatedly relapsed after stopping treatment. MRSA was consistently isolated from airway specimens during each relapse. Extended oral antibiotic treatment with trimethoprim/sulfamethoxazole (TMP/SMX) for 6 months achieved infection control. Whole-genome sequencing of the isolated strain revealed that the causative agent was sequence type (ST)1/staphylococcal cassette chromosome mec (SCCmec) type IVa, a clone that is rapidly increasing in Japan. DISCUSSION ANDCONCLUSIONS:
This patient had an unusual course of MRSA bronchopneumonia with repeated relapses. Although the choice of antibiotics for long-term use in MRSA respiratory tract infections has not been well established, TMP/SMX was effective and well tolerated for long-term therapy in this case. The clinical course of infections related to the rapid emerging clone, ST1/SCCmec type IVa warrants further attention.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Staphylococcal Infections
/
Bronchopneumonia
/
Community-Acquired Infections
/
Methicillin-Resistant Staphylococcus aureus
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Year:
2024
Type:
Article