Apolipoprotein E and Alzheimer's disease pathology in African American older adults.
Neurobiol Aging
; 139: 11-19, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38582070
ABSTRACT
The apolipoprotein-E4 (APOE*4) and apolipoprotein-E2 (APOE*2) alleles are more common in African American versus non-Hispanic white populations, but relationships of both alleles with Alzheimer's disease (AD) pathology among African American individuals are unclear. We measured APOE allele and ß-amyloid (Aß) and tau using blood samples and positron emission tomography (PET) images, respectively. Individual regression models tested associations of each APOE allele with Aß or tau PET overall, stratified by racialized group, and with a racialized group interaction. We included 358 older adults (42% African American) with Aß PET, 134 (29% African American) of whom had tau PET. APOE*4 was associated with higher Aß in non-Hispanic white (P < 0.0001), but not African American (P = 0.64) participants; racialized group modified the association between APOE*4 and Aß (P < 0.0001). There were no other racialized group differences. These results suggest that the association of APOE*4 and Aß differs between African American and non-Hispanic white populations. Other drivers of AD pathology in African American populations should be identified as potential therapeutic targets.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Black or African American
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Amyloid beta-Peptides
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Tau Proteins
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Positron-Emission Tomography
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Alzheimer Disease
Limits:
Aged
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Aged80
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Female
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Humans
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Male
Language:
En
Year:
2024
Type:
Article