HLA-typing in oral submucous fibrosis.
Tissue Antigens
; 26(2): 138-42, 1985 Aug.
Article
in En
| MEDLINE
| ID: mdl-3864289
ABSTRACT
Oral submucous fibrosis (OSF) is a disease of the mouth and oropharynx characterised by progressive deposition of collagen leading to severe limitation of movement of the jaw in advanced cases. It is almost completely confined to inhabitants of, or migrants from India who chew 'betel nut'. The histopathological and clinical features suggest that autoimmune mechanisms may be involved. Because all chronic autoimmune diseases show disturbance in the frequencies of HLA antigens, we have HLA typed 50 OSF patients and a similar number of healthy subjects of the same ethnic origin. Raised frequencies of A10 and DR3 were observed. The results support the concept that OSF is a chronic autoimmune disease, initiated by constituents of betel nut, and occurring in genetically susceptible individuals. Genes situated in the HLA region are important determinants of genetic susceptibility in OSF.
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Database:
MEDLINE
Main subject:
Histocompatibility Antigens Class II
/
HLA Antigens
/
Mouth Diseases
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Year:
1985
Type:
Article