ABSTRACT
Introduction:
Hematopoietic stem cell transplantation (HSCT) recipients are at increased
risk of
cardiovascular diseases. In our study, we aimed to find subclinical changes in myocardial
tissue after HSCT with the help of cardiovascular
magnetic resonance (CMR)
tissue imaging
techniques.
Methods:
The data of 44
patients undergoing autologous and allogeneic HSCT in the
Hospital of Lithuanian
University of
Health Sciences Kaunas Clinics from October 2021 to February 2023 were analyzed.
Bioethics approval for the
prospective study was obtained (No BE-2-96). CMR was performed two times before enrolling for the HSCT
procedure (before starting mobilization
chemotherapy for autologous HSCT and before starting the conditioning regimen for allogeneic HSCT) and 12 ± 1 months after HSCT. LV end-diastolic volume, LV end-systolic volume, LV mass and values indexed to
body surface area (BSA), and LV ejection fraction were calculated. T1 and T2 mapping values were measured.
Results:
There was a statistically significant change in T1 mapping values. Before HSCT, mean T1 mapping was 1226.13 ± 39.74 ms, and after HSCT, it was 1248.70 ± 41.07 ms (p = 0.01). The other
parameters did not differ significantly.
Conclusions:
Increases in T1 mapping values following HSCT can show the progress of diffuse myocardial
fibrosis and may reflect subclinical
injury. T2 mapping values remain the same and do not show
edema and active
inflammation processes at 12 months after HSCT.
