The role of CELF family in neurodevelopment and neurodevelopmental disorders.
Neurobiol Dis
; 197: 106525, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38729272
ABSTRACT
RNA-binding proteins (RBPs) bind to RNAs and are crucial for regulating RNA splicing, stability, translation, and transport. Among these proteins, the CUGBP Elav-like family (CELF) is a highly conserved group crucial for posttranscriptional regulation by binding to CUG repeats. Comprising CELF1-6, this family exhibits diverse expression patterns and functions. Dysregulation of CELF has been implicated in various neural disorders, encompassing both neurodegenerative and neurodevelopmental conditions, such as Alzheimer's disease and autism. This article aims to provide a comprehensive summary of the CELF family's role in neurodevelopment and neurodevelopmental disorders. Understanding CELF's mechanisms may offer clues for potential therapeutic strategies by regulating their targets in neurodevelopmental disorders.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
CELF Proteins
/
Neurodevelopmental Disorders
Limits:
Animals
/
Humans
Language:
En
Year:
2024
Type:
Article