Progresses on genetic susceptibility of COVID-19.
Yi Chuan
; 45(11): 963-975, 2023 Nov 20.
Article
in En
| MEDLINE
| ID: mdl-38764262
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). Genetic factors might influence susceptibility to the SARS-CoV-2 infection or disease severity. Genome-wide association studies (GWASs) have identified multiple susceptible genes related to COVID-19 phenotypes, providing the scientific basis for the COVID-19 prevention and treatment. In this review, we summarize the recent progresses of COVID-19 susceptible genes, including the GWASs on multiple phenotypes of COVID-19, GWASs of COVID-19 in multiple ethnic populations, GWASs of COVID-19 based on multiple types of genetic variations, and the fine-mapping of the regions surrounding the susceptible genes.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Genetic Predisposition to Disease
/
Genome-Wide Association Study
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SARS-CoV-2
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COVID-19
Limits:
Humans
Language:
En
Year:
2023
Type:
Article