Laburnicolamine: A Rare Penillic Acid Congener from the Nematode Cyst-Associated Fungus Laburnicola nematophila.
Chem Biodivers
; 21(8): e202401152, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38771298
ABSTRACT
A chemical investigation of a methanol extract derived from a solid-state rice culture of the nematode-cyst associated fungus Laburnicola nematophila K01 led to the isolation and characterization of a previously undescribed penillic acid analogue named laburnicolamine (1). The chemical structure was elucidated through comprehensive 1D and 2Dâ
NMR spectroscopic analyses in methanol-d4 and DMSO-d6, alongside with HR-ESI-MS spectrometry. The absolute configuration of 1 was concluded through the electronic circular dichroism (ECD) and time-dependent density functional theory-ECD (TDDFT-ECD) computations compared to its acquired spectrum. Biological assays revealed that compound 1 exhibited no significant cytotoxic, antimicrobial, or nematicidal activity.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Microbial Sensitivity Tests
Limits:
Animals
/
Humans
Language:
En
Year:
2024
Type:
Article