Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives.
Mil Med Res
; 11(1): 35, 2024 Jun 04.
Article
in En
| MEDLINE
| ID: mdl-38835066
ABSTRACT
Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NENs. Historically, GEP-NENs have been regarded as infrequent and slow-growing malignancies; however, recent data have demonstrated that the worldwide prevalence and incidence of GEP-NENs have increased exponentially over the last three decades. In addition, an increasing number of studies have proven that GEP-NENs result in a limited life expectancy. These findings suggested that the natural biology of GEP-NENs is more aggressive than commonly assumed. Therefore, there is an urgent need for advanced researches focusing on the diagnosis and management of patients with GEP-NENs. In this review, we have summarized the limitations and recent advancements in our comprehension of the epidemiology, clinical presentations, pathology, molecular biology, diagnosis, and treatment of GEP-NETs to identify factors contributing to delays in diagnosis and timely treatment of these patients.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pancreatic Neoplasms
/
Stomach Neoplasms
/
Neuroendocrine Tumors
Limits:
Humans
Language:
En
Year:
2024
Type:
Article