Association of Cough Severity with Asthma Control and Quality of Life in Patients with Severe Asthma.

Lee, Hwa Young; Lee, Youngsoo; Lee, Ji-Hyang; Lee, Seung-Eun; Sim, Da Woon; Kang, Noeul; Kim, Joo-Hee; Kang, Sung-Yoon; Sohn, Kyoung-Hee; Nam, Young Hee; Kim, Sujeong; Park, Chan Sun; Kim, So Ri; An, Jin; Kim, Byung-Keun; Jin, Hyun Jung; Park, So-Young; Lee, Byung-Jae; Lee, Sook Young; Park, Hae-Sim; Cho, You Sook; Kim, Sang-Heon; Song, Woo-Jung

Lee, Hwa Young; Lee, Youngsoo; Lee, Ji-Hyang; Lee, Seung-Eun; Sim, Da Woon; Kang, Noeul; Kim, Joo-Hee; Kang, Sung-Yoon; Sohn, Kyoung-Hee; Nam, Young Hee; Kim, Sujeong; Park, Chan Sun; Kim, So Ri; An, Jin; Kim, Byung-Keun; Jin, Hyun Jung; Park, So-Young; Lee, Byung-Jae; Lee, Sook Young; Park, Hae-Sim; Cho, You Sook; Kim, Sang-Heon; Song, Woo-Jung.

Affiliation

Lee HY; Division of Allergy, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee Y; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Lee JH; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea.
Lee SE; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Sim DW; Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
Kang N; Department of Allergy and Clinical Immunology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
Kim JH; Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.
Kang SY; Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea.
Sohn KH; Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
Nam YH; Division of Pulmonology and Allergy, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Kim S; Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Park CS; Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Kim SR; Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Korea.
An J; Division of Respiratory Medicine and Allergy, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
Kim BK; Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.
Jin HJ; Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Park SY; Division of Pulmonology and Allergy, Department of Internal Medicine, Yeungnam University Medical Center, College of Medicine, Yeungnam University, Daegu, Korea.
Lee BJ; Department of Internal Medicine, Chung-Ang University College of Medicine, Gwangmyeong, Korea.
Lee SY; Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.
Park HS; Division of Allergy, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Cho YS; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Kim SH; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea.
Song WJ; Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Lung ; 2024 Jun 07.

Article in En | MEDLINE | ID: mdl-38847887

ABSTRACT

ABSTRACT

PURPOSE:

Symptoms are important components in determining asthma control and in the adjustment of treatment levels. However, clinical relevance of cough in severe asthma is not well-understood. This study aimed to evaluate the severity and association of cough with patient-reported outcomes (PROs) in patients with severe asthma.

METHODS:

This study analyzed cross-sectional data from the Korean Severe Asthma Registry. The severity of coughing and wheezing symptoms was assessed using a Visual Analog Scale (VAS) ranging from 0 to 100 for each symptom. Additionally, PROs included the Asthma Control Test (ACT), the Severe Asthma Questionnaire (SAQ), and the EuroQoL 5-Dimension (EQ-5D) index. Multivariate linear regression analysis was employed to explore the relationship between cough severity and other PRO scores.

RESULTS:

A total of 498 patients with severe asthma (age 57.9 ± 13.1 years, females 60.2%) were analyzed. The cough VAS score was higher than the wheeze score (median 30, [interquartile range 10-50] vs. 20 [0-50]; P < 0.001). Additionally, 22.5% of patients ranked in a higher tertile for cough severity compared to wheezing, while 18.5% ranked higher for wheezing severity than cough. Significant correlations were observed between cough and wheeze VAS scores (r = 0.61, P < 0.05) and between each symptom's VAS score and the SAQ (cough r = -0.41, P < 0.001; wheeze r = -0.52, P < 0.001), ACT scores (cough r = -0.50, P < 0.001; wheeze r = -0.63, P < 0.001) and EQ-5D index (cough r = -0.40, P < 0.001; wheeze r = -0.45, P < 0.001). In univariate regression analysis, the cough VAS score had weaker descriptive power (R2) values than the wheeze VAS score in relation to the PRO measures. Nevertheless, cough severity remained significantly associated with ACT, SAQ scores and EQ-5D index in multivariate analyses adjusted for wheeze severity and other confounders.