Disulfidptosis: A new type of cell death.

Xiao, Fei; Li, Hui-Li; Yang, Bei; Che, Hao; Xu, Fei; Li, Gang; Zhou, Cheng-Hui; Wang, Sheng.

Affiliation

Xiao F; Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Li HL; Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Yang B; Department of Emergency, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Che H; Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Xu F; Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Li G; Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Zhou CH; Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.
Wang S; Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. chenghuizhou@vip.163.com.

Apoptosis ; 29(9-10): 1309-1329, 2024 Oct.

Article in En | MEDLINE | ID: mdl-38886311

ABSTRACT

Disulfidptosis is a novel form of cell death that is distinguishable from established programmed cell death pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and oxeiptosis. This process is characterized by the rapid depletion of nicotinamide adenine dinucleotide phosphate (NADPH) in cells and high expression of solute carrier family 7 member 11 (SLC7A11) during glucose starvation, resulting in abnormal cystine accumulation, which subsequently induces andabnormal disulfide bond formation in actin cytoskeleton proteins, culminating in actin network collapse and disulfidptosis. This review aimed to summarize the underlying mechanisms, influencing factors, comparisons with traditional cell death pathways, associations with related diseases, application prospects, and future research directions related to disulfidptosis.

Subject(s)

Cell Death; Humans; Cell Death/genetics; Animals; Apoptosis/genetics; NADP/metabolism; Autophagy/genetics; Glucose/metabolism; Ferroptosis/genetics

Key words

Cystine; Disulfide bond; Disulfidptosis; Glucose starvation; NADPH; SLC7A11