Your browser doesn't support javascript.
loading
MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis.
El Morr, Yara; Fürstenheim, Mariela; Mestdagh, Martin; Franciszkiewicz, Katarzyna; Salou, Marion; Morvan, Claire; Dupré, Thierry; Vorobev, Alexey; Jneid, Bakhos; Premel, Virginie; Darbois, Aurélie; Perrin, Laetitia; Mondot, Stanislas; Colombeau, Ludovic; Bugaut, Hélène; du Halgouet, Anastasia; Richon, Sophie; Procopio, Emanuele; Maurin, Mathieu; Philippe, Catherine; Rodriguez, Raphael; Lantz, Olivier; Legoux, François.
Affiliation
  • El Morr Y; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Fürstenheim M; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Mestdagh M; Université Paris Cité, Paris, France.
  • Franciszkiewicz K; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Salou M; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Morvan C; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Dupré T; Institut Pasteur, Université Paris Cité, UMR CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, F-75015 Paris, France.
  • Vorobev A; Laboratoire de Biochimie, Hôpital Bichat AP-HP, Université de Paris, Paris, France.
  • Jneid B; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Premel V; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Darbois A; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Perrin L; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Mondot S; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Colombeau L; Institut Micalis, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
  • Bugaut H; CNRS UMR 3666, INSERM U1143, Chemical Biology of Cancer Laboratory, PSL University, Institut Curie, 75005 Paris, France.
  • du Halgouet A; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Richon S; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Procopio E; Institut Curie, PSL Research University, CNRS UMR144, Paris, France.
  • Maurin M; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Philippe C; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
  • Rodriguez R; Institut Micalis, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
  • Lantz O; CNRS UMR 3666, INSERM U1143, Chemical Biology of Cancer Laboratory, PSL University, Institut Curie, 75005 Paris, France.
  • Legoux F; Institut Curie, PSL University, Inserm U932, Immunity and Cancer, Paris, France.
Sci Immunol ; 9(96): eadi8954, 2024 Jun 21.
Article in En | MEDLINE | ID: mdl-38905325
ABSTRACT
Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors and responds to such changes remains unclear. Here, we describe a protective mechanism by which mucosal-associated invariant T (MAIT) cells detect microbiota metabolites produced upon intestinal inflammation and promote tissue repair. At steady state, MAIT ligands derived from the riboflavin biosynthesis pathway were produced by aerotolerant bacteria residing in the colonic mucosa. Experimental colitis triggered luminal expansion of riboflavin-producing bacteria, leading to increased production of MAIT ligands. Modulation of intestinal oxygen levels suggested a role for oxygen in inducing MAIT ligand production. MAIT ligands produced in the colon rapidly crossed the intestinal barrier and activated MAIT cells, which expressed tissue-repair genes and produced barrier-promoting mediators during colitis. Mice lacking MAIT cells were more susceptible to colitis and colitis-driven colorectal cancer. Thus, MAIT cells are sensitive to a bacterial metabolic pathway indicative of intestinal inflammation.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Colitis / Dysbiosis / Gastrointestinal Microbiome / Mucosal-Associated Invariant T Cells / Mice, Inbred C57BL Limits: Animals Language: En Year: 2024 Type: Article

Full text: 1 Database: MEDLINE Main subject: Colitis / Dysbiosis / Gastrointestinal Microbiome / Mucosal-Associated Invariant T Cells / Mice, Inbred C57BL Limits: Animals Language: En Year: 2024 Type: Article