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Changes in thyroid hormones predict weight regain in patients with obesity who undergo metabolic surgery.
Tang, Yi; Liu, Wei; Wang, Wuhao; Zhao, Huandong; Lu, Zongshi; Li, Qiang; Yan, Zhencheng; He, Hongbo; Zhao, Zhigang; Ke, Zhigang; Li, Fan; Tong, Weidong; Sun, Fang; Zhu, Zhiming.
Affiliation
  • Tang Y; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Liu W; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Wang W; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Zhao H; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Lu Z; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Li Q; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Yan Z; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • He H; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Zhao Z; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Ke Z; Department of General Surgery, Daping Hospital, Army Medical University of PLA, Chongqing, China.
  • Li F; Department of General Surgery, Daping Hospital, Army Medical University of PLA, Chongqing, China.
  • Tong W; Department of General Surgery, Daping Hospital, Army Medical University of PLA, Chongqing, China.
  • Sun F; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
  • Zhu Z; Department of Hypertension and Endocrinology, Daping Hospital, Army Medical University of PLA, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Chongqing, China.
Diabetes Obes Metab ; 2024 Jun 25.
Article in En | MEDLINE | ID: mdl-38924605
ABSTRACT

AIM:

To investigate the relationship between thyroid function and weight regain in patients with obesity after metabolic surgery.

METHODS:

This retrospective study enrolled 162 patients who underwent metabolic surgery. Correlations between decreases in thyroid hormone levels and changes in weight, waist circumference (WC) and the Chinese visceral adiposity index (CVAI) were assessed. Binary logistic regression and receiver operating characteristic (ROC) curves were used to identify predictors and clinically useful cut-off values, respectively.

RESULTS:

The levels of thyroid-stimulating hormone (TSH) and free triiodothyronine (FT3) decreased markedly at 1 year after surgery, as did weight, body mass index (BMI), triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, WC and CVAI. Decreases in TSH and FT3 after metabolic surgery were associated with changes in weight, BMI and CVAI. Binary logistic regression and ROC curve analyses confirmed that decreases in TSH can predict good weight loss after metabolic surgery to some extent. Finally, binary logistic regression and ROC curve analyses confirmed that changes in TSH can predict weight regain after metabolic surgery.

CONCLUSIONS:

Changes in TSH and FT3 after metabolic surgery were correlated with changes in weight and CVAI. Changes in thyroid hormones can predict weight regain in patients with obesity who underwent metabolic surgery.
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Full text: 1 Database: MEDLINE Language: En Year: 2024 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Language: En Year: 2024 Type: Article