Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol.
Int J Mol Sci
; 25(12)2024 Jun 19.
Article
in En
| MEDLINE
| ID: mdl-38928443
ABSTRACT
This paper presents the work performed to transition a lab-scale synthesis (1 g) to a large-scale (400 g) synthesis of the 3-5-diamino-1H-Pyrazole Disperazol, a new pharmaceutical for treatment of antibiotic-resistant Pseudomonas aeruginosa biofilm infections. The potentially hazardous diazotisation step in the lab-scale synthesis was transformed to a safe and easy-to-handle flow chemistry step. Additionally, the paper presents an OSHA-recommended safety assessment of active compound E, as performed by Fauske and Associates, LLC, Burr Ridge, IL, USA.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pseudomonas aeruginosa
/
Pyrazoles
Limits:
Humans
Language:
En
Year:
2024
Type:
Article