ABSTRACT
BACKGROUND:
Continuous renal replacement therapy (CRRT) has become the standard modality of
renal replacement therapy (RRT) in
critically ill patients. However,
consensus is lacking regarding the criteria for discontinuing CRRT. Here we validated the usefulness of the prediction model for successful discontinuation of CRRT in a multicenter retrospective cohort.
METHODS:
One temporal cohort and four external cohorts included 1,517
patients with
acute kidney injury who underwent CRRT for >2 days from 2018 to 2020. The model was composed of four variables
urine output,
blood urea nitrogen,
serum potassium, and
mean arterial pressure. Successful discontinuation of CRRT was defined as the absence of an RRT requirement for 7 days thereafter.
RESULTS:
The area under the
receiver operating characteristic curve (AUROC) was 0.74 (95%
confidence interval, 0.71-0.76). The
probabilities of successful discontinuation were approximately 17%, 35%, and 70% in the low-score, intermediate-score, and highscore groups, respectively. The model performance was good in four cohorts (AUROC, 0.73-0.75) but poor in one cohort (AUROC, 0.56). In one cohort with poor performance, attending
physicians primarily controlled CRRT
prescription and discontinuation, while in the other four cohorts,
nephrologists determined all important steps in CRRT operation, including
screening for CRRT discontinuation.
CONCLUSION:
The overall performance of our prediction model using four simple variables for successful discontinuation of CRRT was good, except for one cohort where
nephrologists did not actively engage in CRRT operation. These results suggest the need for active engagement of
nephrologists and protocolized management for CRRT discontinuation.