Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future.
Adv Exp Med Biol
; 1445: 3-10, 2024.
Article
in En
| MEDLINE
| ID: mdl-38967746
ABSTRACT
The canonical theory of immunology stating that "Immunoglobulin (Ig) is produced by B lymphocytes and exerts antibody activity" has been established since the 1970s. However, the discovery of non B cell-derived Igs (non B-Igs), which can exert multiple biological activities in addition to their antibody activities, necessitates a reevaluation of the classic concept of Ig. This has been documented with a number of characteristics related to their structure, modification, genetic regulation as well as the functions associated with clinical conditions, particularly multiple cancers. The discovery of non B-Ig provides us with a new perspective to better understand not only basic immunology, but also various Ig-related clinical manifestations including autoimmune diseases, chronic inflammation, and anaphylaxis. Notably, non B-Ig can directly promote the occurrence of malignant tumours.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Immunoglobulins
Limits:
Animals
/
Humans
Language:
En
Year:
2024
Type:
Article