Fully closed conformation of penicillin-binding protein revealed by structure of PBP2 from Acinetobacter baumannii.

Jang, Hyunseok; Kim, Chang Min; Hong, Eunmi; Park, Hyun Ho

Jang, Hyunseok; Kim, Chang Min; Hong, Eunmi; Park, Hyun Ho.

Affiliation

Jang H; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea.
Kim CM; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Hong E; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Republic of Korea.
Park HH; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea. Electronic address: xrayleox@cau.ac.kr.

Biochem Biophys Res Commun ; 729: 150368, 2024 Oct 15.

Article in En | MEDLINE | ID: mdl-38986258

Subject(s)

Acinetobacter baumannii; Penicillin-Binding Proteins; Protein Conformation; Acinetobacter baumannii/metabolism; Acinetobacter baumannii/chemistry; Penicillin-Binding Proteins/chemistry; Penicillin-Binding Proteins/metabolism; Penicillin-Binding Proteins/genetics; Crystallography, X-Ray; Models, Molecular; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Bacterial Proteins/genetics; Anti-Bacterial Agents/pharmacology; Anti-Bacterial Agents/chemistry; Amino Acid Sequence

Key words

Acinetobacter baumannii; Crystal structure; PBP2; Penicillin; Superbug

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Full text: 1 Database: MEDLINE Main subject: Protein Conformation / Acinetobacter baumannii / Penicillin-Binding Proteins Language: En Year: 2024 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Protein Conformation / Acinetobacter baumannii / Penicillin-Binding Proteins Language: En Year: 2024 Type: Article