ABSTRACT
Introduction:
Gastric cancer has been reported to occur with mild to moderate mucosal
atrophy, particularly after the eradication of
Helicobacter pylori (HP) more than 10 years previously. However, no conclusion has been reached on how many years of
esophagogastroduodenoscopy should be performed after HP eradication. Presentation of case This was a case of gastric
carcinoma of the fundic gland type (GCFGT) 32 years after the eradication of HP, which is the longest posteradication period reported. A 62-year-old
male patient was diagnosed with GCFGT after HP eradication and regular
esophagogastroduodenoscopy, which revealed a
white raised lesion on the anterior wall of the upper part of the body.
Endoscopic submucosal dissection was performed for GCFGT, and the vertical and horizontal margins were negative. Clinical
discussion:
In this case, HP was eradicated in 1990, and GCFGT developed 32 years later. To the best of our
knowledge, this is the longest case in which
gastric cancer appeared after HP eradication. HP eradication
therapy for a
duodenal ulcer was first reported in 1990, supporting that this is the longest case.
Conclusions:
This is the first case of
gastric cancer more than 20 years after the eradication of HP. The endoscopic findings of this case are typical of GCFGT and may be useful when encountering such cases in the
future. Therefore, the
risk of
gastric cancer should be considered for an extended period even after the eradication of HP, and regular
esophagogastroduodenoscopy is recommended even after the eradication of HP.
