Sensing DNA as danger: The discovery of cGAS.
Immunity
; 57(10): 2251-2254, 2024 Oct 08.
Article
in En
| MEDLINE
| ID: mdl-39303723
ABSTRACT
Insight into how the immune system recognizes and responds to pathogens had led to landmark advances in biology and medicine in the last decades. This year's Albert Lasker Award for Basic Medical Research honors Zhijian "James" Chen for the discovery of cGAS, the enzyme that senses foreign and "pathogenic" self-DNA-self-DNA aberrantly located in intracellular compartments. The definition of the cGAS-STING pathway opens new horizons for the understanding and treatment of human disease.
Full text:
1
Database:
MEDLINE
Main subject:
DNA
/
Nucleotidyltransferases
Limits:
Animals
/
Humans
Language:
En
Year:
2024
Type:
Article