Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.

Bères, J; Bentrude, W G; Balzarini, J; De Clercq, E; Otvös, L

Bères, J; Bentrude, W G; Balzarini, J; De Clercq, E; Otvös, L.

J Med Chem ; 29(4): 494-9, 1986 Apr.

Article in En | MEDLINE | ID: mdl-3959027

Subject(s)

Antineoplastic Agents/chemical synthesis; Antiviral Agents/chemical synthesis; Nucleotides, Cyclic/chemical synthesis; Uracil Nucleotides/chemical synthesis; Uridine Monophosphate/chemical synthesis; Animals; Antineoplastic Agents/pharmacology; Antiviral Agents/pharmacology; Cell Line; Humans; Leukemia L1210/drug therapy; Magnetic Resonance Spectroscopy; Mice; Nucleotides, Cyclic/pharmacology; Structure-Activity Relationship; Thymidine Kinase/analysis; Thymidylate Synthase/antagonists & inhibitors; Uridine Monophosphate/analogs & derivatives; Uridine Monophosphate/pharmacology

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Database: MEDLINE Main subject: Antiviral Agents / Uracil Nucleotides / Uridine Monophosphate / Antineoplastic Agents / Nucleotides, Cyclic Limits: Animals / Humans Language: En Year: 1986 Type: Article

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