Host defense against Neisseria meningitidis requires a complement-dependent bactericidal activity.
Science
; 205(4403): 298-9, 1979 Jul 20.
Article
in En
| MEDLINE
| ID: mdl-451601
ABSTRACT
Some individuals, with severe or recurrent infection with Neisseria species, have been identified as lacking a component in the terminal attack sequence of complement (complement components 5 to 9). The relevance of the terminal attack sequence to various phases of host defense was tested with the use of the C-11 strain of meningococci and human serum genetically deficient in complement component 8 (C8-D). The C8-D serum was comparable to normal serum in supporting ingestion and intracellular killing by leukocytes but was not bactericidal in the fluid phase unless reconstituted with C8. Thus, serum complement-dependent bactericidal activity may be especially critical for the host's defense against invasive Neisseria species.
Search on Google
Database:
MEDLINE
Main subject:
Blood Bactericidal Activity
/
Complement C8
/
Meningitis, Meningococcal
/
Neutrophils
Limits:
Humans
Language:
En
Year:
1979
Type:
Article