Microtubule function in immune and nonimmune lymphocyte-mediated cytotoxicity.

Strom, T B; Garovoy, M R; Carpenter, D B; Merrill, J P

Strom, T B; Garovoy, M R; Carpenter, D B; Merrill, J P.

Science ; 181(4095): 171-3, 1973 Jul 13.

Article in En | MEDLINE | ID: mdl-4541240

ABSTRACT

ABSTRACT

Disaggregation of microtubular subunits in effector lymphocytes inhibits their ability to injure target cells. The inhibition is not reversed by denterium oxide, an agent known to stablize microtubular subunits.

Subject(s)

Lymphocytes/immunology; Microtubules/physiology; Animals; Antigen-Antibody Reactions; Chromium Isotopes; Colchicine/pharmacology; Cytotoxicity Tests, Immunologic; Deuterium/pharmacology; Dose-Response Relationship, Drug; Male; Microtubules/drug effects; Oxides/pharmacology; Rats; Spleen/immunology; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; Vinblastine/pharmacology

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