Vitamin B12 and the megaloblastic development.

Haurani, F I

Haurani, F I.

Science ; 182(4107): 78-9, 1973 Oct 05.

Article in En | MEDLINE | ID: mdl-4730057

ABSTRACT

ABSTRACT

In patients with vitamin B(12) deficiency, phytohemagglutinin-stimulated cultured lymphocytes had little or no thymidylate synthetase activity. Ample activity was found in such lymphocytes from normal individuals and patients with folic acid deficiency or pernicious anemia in remission. It therefore appears that the megaloblastosis that is associated with vitamin B(12) deficiency is related to low thymidylate synthetase activity.

Subject(s)

Anemia, Pernicious/enzymology; Lymphocytes/enzymology; Methyltransferases/metabolism; Vitamin B 12 Deficiency/enzymology; Bone Marrow Cells; Carbon Isotopes; Erythrocytes; Folic Acid Deficiency/enzymology; Humans; Lectins/pharmacology; Lymphocytes/drug effects; Nucleosides/metabolism; Thymidylate Synthase/blood; Thymidylate Synthase/metabolism; Vitamin B 12 Deficiency/blood

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Database: MEDLINE Main subject: Vitamin B 12 Deficiency / Lymphocytes / Anemia, Pernicious / Methyltransferases Limits: Humans Language: En Year: 1973 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Vitamin B 12 Deficiency / Lymphocytes / Anemia, Pernicious / Methyltransferases Limits: Humans Language: En Year: 1973 Type: Article