HLA-B27 and modified bone formation.
Lancet
; 1(7953): 230-1, 1976 Jan 31.
Article
in En
| MEDLINE
| ID: mdl-55536
ABSTRACT
Of the many associations between histocompatibility antigens and human diseases a prominent one is that between HLA-B27 and inflammatory arthropathies. Hypotheses to explain this association include the B27 gene being linked to a specific immune-response gene required for disease expression and the B27 antigen acting via molecular mimicry with a microorganism or as a microorganism receptor. Alternatively, the HLA-B27 gene might be closely related to a gene which influences bone formation. The finding of a significant association between B27 and Forestier's disease, a disease characterised by abundant new bone formation, supports such a hypothesis.
Search on Google
Database:
MEDLINE
Main subject:
Osteogenesis
/
Spondylitis, Ankylosing
/
Exostoses
/
Histocompatibility Antigens
/
HLA Antigens
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
1976
Type:
Article