Regulation of the strength of adenosine modulation in the hippocampus by a differential distribution of the density of A1 receptors.
Brain Res
; 260(1): 156-9, 1983 Jan 31.
Article
in En
| MEDLINE
| ID: mdl-6297683
ABSTRACT
Correlative studies examining (1) the binding of [3H]cyclohexyladenosine to A1 adenosine receptor sites, and (2) the depressive action of adenosine on evoked activity, were performed in the hippocampal formation. A greater number of A1 sites was observed in the dorsal versus ventral aspect of the hippocampus, and a larger depression of evoked potentials by adenosine was obtained in the dorsal aspect. These observations suggest that a differential density of A1 receptors might control the magnitude of modulatory action by adenosine on hippocampal circuitry.
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Database:
MEDLINE
Main subject:
Adenosine
/
Synaptic Transmission
/
Receptors, Cell Surface
/
Hippocampus
Limits:
Animals
Language:
En
Year:
1983
Type:
Article