A novel peptide delivery system involving peptidase activated prodrugs as antimicrobial agents. Synthesis and biological activity of peptidyl derivatives of 5-fluorouracil.

Kingsbury, W D; Boehm, J C; Mehta, R J; Grappel, S F; Gilvarg, C

Kingsbury, W D; Boehm, J C; Mehta, R J; Grappel, S F; Gilvarg, C.

J Med Chem ; 27(11): 1447-51, 1984 Nov.

Article in En | MEDLINE | ID: mdl-6387121

Subject(s)

Fluorouracil/analogs & derivatives; Peptide Hydrolases/metabolism; Candida albicans/drug effects; Chromatography, High Pressure Liquid; Escherichia coli/drug effects; Fluorouracil/pharmacology; Methods; Microbial Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship

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