[Neutral alpha glucosidase in human urine as a marker of kidney impairment]. / Neitral'naia al'fa-gliukozidaza mochi cheloveka kak marker povrezhdeniia pochek.

ABSTRACT

Distinct correlation was found between the activity of neutral alpha-glucosidase in urine and the degree of kidney impairment in 76 patients and in 15 healthy persons. In the patients with non-impaired kidney functions the activity of the enzyme in urine varied within the normal limits (from 12 to 39 microM/hr/mmole of creatinine; normal value being 14.6-15.9 microM), in the patients with moderately expressed disfunction of kidney--from 40 to 79 microM/hr/mmole of creatinine. The enzymatic activity, exceeding 80 microM/hr/mmole of creatinine (up to 227 mM), was observed in cases of severe impairment of the kidney functions. High activity of alpha-glucosidase, correlating with the severity of kidney impairment was found in urine of patients with pyelonephritis albeit the content of protein was quite normal. Interrelationship between the activity of alpha-glucosidase in urine and the state of kidney functions enables to conclude that the enzymatic activity depends on the degree of kidney impairment under various pathological conditions and that estimation of the enzyme activity in urine may be important for diagnosis of kidney diseases as well as for the control of treatment efficiency.