Synthesis and antitumor evaluation of some nitrosourea and nitrogen mustard amino acid derivatives.
J Med Chem
; 27(9): 1222-5, 1984 Sep.
Article
in En
| MEDLINE
| ID: mdl-6471076
ABSTRACT
A series of (2-chloroethyl)nitrosourea and nitrogen mustard amino acid derivatives have been synthesized for antitumor evaluation. Reaction of an appropriate N-protected amino acid with 2-chloroethylamine followed by removal of the N-protecting group and condensation with an active (2-chloroethyl)nitrosocarbamate yielded N-[(2-chloroethyl)nitrosocarbamoyl]amino acid (2-chloroethyl)amides. Antitumor evaluation was performed against leukemia L1210, in vivo, in mice. These derivatives exhibited very interesting activities, particularly the sarcosine and gamma-aminobutyric acid derivatives.
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Database:
MEDLINE
Main subject:
Antineoplastic Agents
/
Nitrogen Mustard Compounds
/
Nitrosourea Compounds
Limits:
Animals
Language:
En
Year:
1984
Type:
Article