Suppression of PHA-induced human T-lymphocyte colony formation following in vivo administration of anti-lymphocyte globulin. Report of one case.

ABSTRACT

The administration of anti-lymphocyte globulin in a patient with pure red cell aplasia completely abrogated the PHA-induced T colony forming capacity of peripheral blood mononuclear cells. The possible mechanisms of the ALG-induced suppression are discussed. It is proposed that T-colony assays may represent an useful tool for monitoring some effects of immunosuppressive drugs on T cells.