CSF GABA levels in Parkinson's disease.
Adv Neurol
; 40: 427-30, 1984.
Article
in En
| MEDLINE
| ID: mdl-6695622
ABSTRACT
CSF levels of GABA were investigated in a group of Parkinson patients without drug treatment and a group of Parkinson patients under treatment with L-DOPA or anticholinergics. Probenecid results in an elevation of CSF GABA levels in healthy persons. The results indicate a significant decrease of GABA levels in CSF in untreated Parkinson patients. Parkinson patients treated with L-DOPA or anticholinergics show nearly normal CSF GABA levels. This may suggest that the altered GABA function in Parkinson's disease is secondary to changes in the dopamine system.
Search on Google
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Probenecid
/
Gamma-Aminobutyric Acid
Limits:
Humans
Language:
En
Year:
1984
Type:
Article