Induction of colon tumors by a single oral dose of 1,2-dimethylhydrazine.
Cancer Lett
; 11(1): 75-9, 1980 Nov.
Article
in En
| MEDLINE
| ID: mdl-7226140
ABSTRACT
Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg). After 1.5 years, the 14 control and 28 treated animals were killed for general autopsy. The incidence of tumor formation in the treated animals was 78.6% as compared to 0% for the control animals. All tumors (1--3/rat) were located in the colon, with the exception of one in the Zymbal's gland of the ear and one in the small intestine. The dosage of 1,2-dimethylhydrazine used in this study is the lowest single oral dose of this carcinogen reported to induce colon tumors.
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Database:
MEDLINE
Main subject:
Colonic Neoplasms
/
Dimethylhydrazines
/
Methylhydrazines
Limits:
Animals
Language:
En
Year:
1980
Type:
Article